Introduction: Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine glands. The spectrum compromises varies from a specific organ to a systemic process with extraglandular manifestations (musculoskeletal, hematological, pulmonary, renal, dermatological and nervous system). In the absence of associated systemic autoimmune disease, are classified as primary SS (SSp). It was proposed to evaluate whether the AntiRo 52, AntiRo 60, AntiLa, ANAs, FR IgA, IgG and IgM autoantibodies, anti alpha fodrine IgA and IgG antibodies, minor salivary gland biopsy are related to clinical expressions of SSp. Materials and methods: Autoantibodies were measured in 47 patients with SSp diagnosed by ACR / EULAR 2016 criteria. A survey was completed by researchers to evaluate sociodemographic data and the electronic medical history of the Fernando Chalem Institute of Rheumatology Foundation in Bogotá - Colombia was reviewed to assess extraglandular involvement and biopsy of the minor salivary gland. Results: We found an association of IgA (p: 0.037) and IgG (p: 0.01) antibodies with neuropathy and of IgA and antiRo 52 alphafodrine antibodies with pulmonary involvement (p: 0.014 and p: 0.031 respectively). AntiLA antibodies have a clinical association with hematologic manifestations due to leukopenia (p: 0.011) lymphopenia (p: 0.023) and anemia (p: 0.09). We found no association of minor salivary gland biopsy and extraglandular manifestations of SSp. Conclusions: These findings indicate that an activated immune system, reflected by the hyperactivity of B cells, with the formation of autoantibodies and hypergammaglobulinemia, is associated with more systemic manifestations in patients with SSp.
