Science journalism has progressively managed to have a space in the generalist media to be able to provide information in this area. With regard to health, the social understanding of diseases especially those that are rare, they become a fundamental task for journalists in the creation of content on the subject with less scientific language for a larger audience. This paper seeks to study how the media El Tiempo and El Espectador have presented and disseminated the content of the three orphan diseases: Sjögren's syndrome, Guillain-Barre syndrome and Multiple Sclerosis in the years 2016 to 2020. The analysis is based on the communication models of science: Deficit, Participatory and Critical Understanding of Science in Public (CUSP), also in some approaches to multimedia and semiotic-narrative journalism of information.