Background: Hemodialysis requires a large amount of water. With the development of the new filters of high efficiency the depuration of the particles depends on lower degree of the speed of the QD liquid, which would allow in prescribing lower water quantities. Objective: Evaluate the effect of Qd reduction on mortality and adequacy of dialysis in adult patients with weighing less than 70 kg. Methodology: This is an observational study comparing two hemodialysis values of Qd (400 ml / min Vs 500 ml / min), evaluating death, Kt / V and general adaptation laboratories. Results: We included 71 patients with an average age of 62.5 years (SD 15.2). There were no statistically significant differences in mortality or adequacy of kt / V at 2 years of follow-up. Conclusion: The reduction of dialysate fluid flow (QD) in patients with low volumes of distribution allows an adequate dose of dialysis in terms of Kt / V without effects on mortality being a financially and environmentally profitable measure.