Depression is a known comorbidity of COPD, although the diagnosis is not frequent. This study determined the prevalence of depression and associated factors in this patients in a comprehensive care program. Introduction: Depression in COPD has been related to a decrease in quality of life and adherence and an increased risk of exacerbations and hospitalizations. Methods: In 2017, a cross-sectional study of 322 COPD patients from a comprehensive care program in Colombia was conducted. Sociodemographic, clinical and paraclinical factors were obtained from the program's monitoring bases. The PHQ9 questionnaire evaluated the presence of depression. The logistic regression was determined to estimate OR and confidence intervals 95% (CI). Results: The prevalence of depression was 35.4%(114) and anxiety was 10.2%(33). COPD patients were mostly men (63%), an average age of (75) years. The risk factor for COPD was tobacco (58%), however, only (2%) symptoms active smoking, exacerbations (41%), hospitalizations (15.2%). The multivariate analysis showed factors associated with the presence of depression: female sex (RP: 1.37 95% CI 1.04 - 1.81), and exacerbations (RP: 2.05 95% CI 1.16 - 3, 62) Conclusions and recommendations: In COPD patients, depression was associated with the female sex, and hospitalizations due to respiratory causes. We recommend systematically including the evaluation of depression in the follow-up of these patients.