A genetic - population study was conducted into two age groups from Colombian population in order to assess genetic differences related to the MTHFR 677C>T for genetic events that support the persistence of this polymorphism in human species because this has been associated with multiple diseases. Thus individuals were genotyping, genotypes and allele frequencies were analyzed and different genetic-population tests were performed.Contrary to what was observed in Colombian populations checked before the absence of Hardy-Weinberg equilibrium in the group of children and population structures among adults suggesting different demographic and cultural histories between these two population groups at the time, which supports the hypothesis about a selection event on this polymorphism in our population.Similarly our data were analyzed together with previous studies at national and global level which supports the possible selective event is caused by the contribution of folic acid that has increased over the past two decades as a result of campaigns fortification flour and supplementation with folic acid pregnant, therefore in this work is proposed a selection model that fits the data found and explaining the relationship between nutritional patterns of the human species through the story explaining the aims set differences in frequencies of this polymorphism to spatial and temporal level.
