This study examines the effect of nationality on the success of entrepreneurship in Colombia, measured by factors such as income level and firm size, identifying the variables that influence the difference in performance between national and migrant entrepreneurs. A mixed methodology was used based on a rigorous review of the literature on the subject and a statistical analysis based on t-Student and Wilcoxon tests of a survey of 770 entrepreneurs located in the departments of Santander, Norte de Santander and Guajira, regions that border Venezuela. The findings reveal that domestic ventures tend to be more successful than migrant ventures. National entrepreneurs reported higher incomes, larger firm sizes, higher educational levels and more entrepreneurial experience. In contrast, it is evident that the proportion of migrants who undertake out of necessity is higher than the percentage of nationals who undertake out of necessity, explaining part of the effect of nationality on entrepreneurship in Colombia. Finally, the development of public policies that are easily accessible to migrants is recommended, focusing on entrepreneurial education and training programs.