Resumen
- Adverse drug reactions are a public health problem and are sometimes attributed to the presence of molecular variants in genes related to drug metabolism. In this study we identified a patient with prolonged awakening episodes after anesthesia. By means of NGS, a current molecular methodology, the causal variants of the phenotype were identified, which allow the establishment of personalized medicine models in her.
- Las reacciones adversas a medicamento son un problema de salud publica y son atribuidas en algunas ocasiones a la presencia de variantes moleculares en genes relacionados con el metabolismo de medicamentos. En este estudio identificamos una paciente con episodios de despertar prolongado luego de acto anestésico. Mediante NGS, una metodología molecular actual, se identificaron las variantes causales del fenotipo, que permiten establecer modelos de medicina personalizada en ella.