Autor
- Juan Manuel Anaya
- Luke S. Heuer
- M. Eric Gershwin
- William M. Ridgway
- Zhe Xiong Lian
Autoimmunity, epitope analysis, and molecular mimicry Artículo académico
Perfil
Resumen
- Infectious agents are potential triggers for autoimmune diseases (ADs) in susceptible individuals, with infection being a key factor in initiating autoimmunity. Epidemiological and experimental evidence suggests molecular mimicry as a plausible mechanism for breaking peripheral tolerance, leading to clinical disease. However, molecular mimicry is not the sole mechanism; other factors, such as deficiencies in central tolerance, bystander activation, epitope spreading, and sustained antigenic stimulation, may also contribute to AD etiology. Advanced methods, including molecular docking simulations, affinity estimation for human leukocyte antigens, and three-dimensional structural analysis of peptides, are increasingly vital for studying molecular mimicry’s role in AD pathogenesis. Further research into peptide conformational analysis is essential for designing effective vaccines and understanding environmental factors in autoimmunity.
autores
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http://vivoweb.org/ontology/core#FacultyMemberAcosta Ampudia, Yeny Yasbleidy
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http://vivoweb.org/ontology/core#FacultyMemberMonsalve Carmona, Diana Marcela
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http://vivoweb.org/ontology/core#FacultyMemberRamírez Santana, Heily Carolina
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http://vivoweb.org/ontology/core#FacultyMemberRojas Quintana, Manuel Eduardo
fecha de publicación
- 2025-12-1
Área temática
Edición
- 97
Identidad
Número Internacional Normalizado de Publicaciones Seriadas (ISSN)
- 0952-7915