Ibrutinib-Related Uveitis in Non-Hodgkin Lymphoma Patients Academic Article

journal

  • Ocular Immunology and Inflammation

abstract

  • Purpose: To report two cases of ibrutinib-related uveitis and review the literature to date. Methods: We report two cases of ibrutinib-related uveitis using CARE guidelines and review the cases reported in the literature. Results: Case 1) A 55-year-old female with recurrent primary central nervous system lymphoma presented with bilateral decreased visual acuity, photophobia, and floaters that started one month after initiating oral treatment with ibrutinib. Chronic non-granulomatous bilateral anterior-intermediate uveitis with macular edema was identified. Secondary causes were ruled out, and a presumptive diagnosis of ibrutinib-related uveitis was made. Case 2) A 57-year-old female with Waldenström macroglobulinemia who was treated with ibrutinib for two years presented with bilateral blurred vision, photophobia, red eyes, and floaters. A diagnosis of non-granulomatous, noninfectious panuveitis with bilateral cystoid macular edema was made. Secondary causes were ruled out, and ibrutinib toxicity was the most likely cause. Conclusion: Ibrutinib-related uveitis is a novel and under-diagnosed clinical entity. The most frequent clinical presentation in the literature is bilateral, non-granulomatous, anterior, and intermediate uveitis. Macular edema is a frequent complication. Uveitis usually requires topical treatment and the suspension of ibrutinib. Switching to second-generation Bruton tyrosine kinase inhibitors is proposed as a potential therapeutic alternative.

publication date

  • 2024-1-1

keywords

  • Agammaglobulinaemia Tyrosine Kinase
  • Anterior Uveitis
  • Central Nervous System
  • Eye
  • Guidelines
  • Intermediate Uveitis
  • Lymphoma
  • Macular Edema
  • Non-Hodgkin's Lymphoma
  • Ocular Vision
  • PCI 32765
  • Panuveitis
  • Photophobia
  • Suspensions
  • Therapeutics
  • Uveitis
  • Visual Acuity
  • Waldenstrom Macroglobulinemia

International Standard Serial Number (ISSN)

  • 0927-3948