Work-up in patients with retinal vasculitis: A systematic review and meta-analysis: International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 2

Autor

Azadeh Mobasserian
Carlos Cifuentes-González
Cheong Fu Yuan Walter
German Mejia-Salgado
Ikhwanuliman Putera
James T. Rosenbaum
John H. Kempen
Jose S. Pulido
Jyotirmay Biswas
Quan Dong Nguyen
Reo Chan
Rina La Distia Nora
Rupesh Agrawal
Sapna Gangaputra
V. Gupta
William Rojas-Carabali
Xin Ying Rachel Song
Yong Le Tong

Resumen

This systematic review and meta-analysis investigate global diagnostic approaches for retinal vasculitis (RV), with a focus on infectious and non-infectious causes. As in our prior report, systematic searches were conducted in 5 databases and registered in PROSPERO (CRD42023489232). Studies included articles on at least 10 patients with RV without publication date or language restrictions. RV was categorized as secondary RV if they were associated with systemic disease, syndromic if they were associated with a syndromic ocular disease without systemic disease, idiopathic RV without association to systemic or syndromic ocular diseases. This report includes 84 studies analyzing 3480 patients with RV. Among infectious causes, tuberculosis tests were frequently reported, with TST/IGRA positivity observed in 31.4 % (95 % CI: 17.2–50.2 %) of de novo RV cases, increasing to 64.7 % (95 % CI: 47.8–78.9 %) in confirmed tubercular RV and 65.7 % (95 % CI: 39.0–85.1 %) in Eales disease. Chest radiograph abnormalities were present in 21.8 % (95 % CI: 12.9–33.8 %) of tubercular RV cases. Non-infectious causes showed notable regional variability. HLA-B51 positivity was 1 % (95 % CI: 0.03–3.1 %) in de novo RV, but rose to 61.4 % (95 % CI: 23.1–89.4 %) in Behçet's RV. Sarcoidosis RV revealed noncaseating granulomas in 80.5 % (95 % CI: 9.7–99.4 %), with angiotensin-converting enzyme elevation in 4.6 % (95 % CI: 2.3–9.1 %). This study highlights significant geographic variability in RV etiologies. Tuberculosis remains a key infectious cause, while non-infectious causes vary regionally. Region-specific diagnostics and Bayesian testing protocols are critical to improving diagnostic accuracy and patient outcomes.

autores

http://vivoweb.org/ontology/core#FacultyMember
De La Torre Cifuentes, Ligia Alejandra

fecha de publicación

2025-1-1

Área temática

Salud y bienestar

VIVO
VIVO

Work-up in patients with retinal vasculitis: A systematic review and meta-analysis: International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 2 Artículo académico

Perfil

Autor

Resumen

autores

fecha de publicación

Área temática

Identidad

Número Internacional Normalizado de Publicaciones Seriadas (ISSN)

Identificador de objeto digital (DOI)

Comprometidos
con la calidad