Unraveling dengue virus-host interactions through transcriptomics: Insights into disease progression and severity signatures Artículo académico

Autor

Axel Vergel
Luz Helena Patiño

Resumen

Dengue virus (DENV) remains a major global health concern, characterized by complex virus-host interactions that are not yet fully understood. Advances in transcriptomic technologies have become crucial for uncovering the molecular mechanisms underlying DENV infection. This review summarizes recent transcriptomic studies, spanning microarrays, bulk RNA sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), virus-inclusive single-cell RNA-seq (ViscRNA-seq), and spatial transcriptomics. that have deepened our understanding of how DENV modulates host gene expression. These approaches have revealed critical immune responses, viral evasion strategies, and gene expression signatures linked to disease progression and severity. Moreover, transcriptomic analyses have facilitated the discovery of potential biomarkers for early diagnosis and novel targets for antiviral therapy. By integrating findings from diverse experimental models and technologies, this review underscores the pivotal role of transcriptomics in elucidating DENV pathogenesis. Collectively, these insights provide a robust foundation for developing improved diagnostics and therapeutic interventions against dengue.

autores

http://vivoweb.org/ontology/core#FacultyMember
Ramírez González, Juan David

fecha de publicación

2026-4-1

Área temática

Salud y bienestar

Edición

213

Número Internacional Normalizado de Publicaciones Seriadas (ISSN)

0882-4010

Identificador de objeto digital (DOI)

https://doi.org/10.1016/j.micpath.2026.108350

Número de páginas

1

Página inicial

108350