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  2. Sandra Carolina Firacative Ropero
Sandra Carolina Firacative Ropero
  • sandra.firacative@urosario.edu.co
  • (601) 2970200 Ext. 3404

Sandra Carolina Firacative Ropero

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  • Profesor asociado de carrera, Escuela de Medicina y Ciencias de la Salud , Universidad del Rosario - 2005
  • Investigador, Grupo de Investigación de Estudios en Microbiología Traslacional y Enfermedades Emergentes - MICROS , Instituto de Medicina Traslacional - IMT - 2000
  • Investigador, Semillero de investigación: Grupo MICROS , Grupo de Investigación de Estudios en Microbiología Traslacional y Enfermedades Emergentes - MICROS - 2000

Áreas de investigación

  • Epidemiology
  • Genetics
  • Immunology
  • Molecular biology
  • Mycology
  • Perfil
  • Formación Académica
  • Publicaciones
  • Proyectos
  • Tutorías
  • Reconocimientos
  • Identidad

Perfil

Perfil Profesional

  • Dr. Carolina Firacative is a biologist from Universidad Nacional de Colombia with more than 15 years of experience in microbiology. She began her work in bacteriology and medical mycology at the Microbiology Group of the National Institute of Health in Bogota, Colombia. In 2010, she joined the University of Sydney, Australia, where she completed her PhD in medicine, with studies in molecular and genetic epidemiology of various human fungal pathogens. In 2015, she joined the University of Leipzig, Germany, with a fellowship from the Alexander von Humboldt Foundation for a postdoctoral stay, working with immunoproteomics of cryptococcosis. In 2018, she joined the MICROS Group of the School of Medicine and Health Sciences of the Universidad del Rosario, where she participates in several projects aimed at understanding different aspects of mycoses of importance in Public Health. Currently she has 37 scientific publications in indexed journals and 2 book chapters on topics related to human mycosis. Currently she has more than 60 scientific publications in indexed journals and 3 book chapters on topics related to human mycosis

    • Formación Académica

    Formación Académica

  • 2006, Bióloga, Universidad Nacional de Colombia - Bogotá D.C.
  • 2015, Doctora en Ciencias Biomédicas, University of Sydney

    • Formación Académica Complementaria

  • 2018, Metodología Estadistica en la Investigación: Limitaciones, Retos y Errores más Comunes, Desarrollo profesoral-Universidad del Rosario
  • 2019, Innovando en el Aprendizaje, Aprendiendo a Innovar, Desarrollo profesoral-Universidad del Rosario
  • 2020, Emocionate con Inteligencia, Desarrollo profesoral-Universidad del Rosario
  • 2020, Ensenanza y Aprendizaje en Tiempos de TransFormación, Desarrollo profesoral-Universidad del Rosario
  • 2020, Stata Básico, Desarrollo profesoral-Universidad del Rosario
  • 2021, The Horizon Europe 2021-2027 Program, Desarrollo profesoral-Universidad del Rosario
  • 2022, Café Maestro, Desarrollo profesoral-Universidad del Rosario
  • 2022, Portafolio Docente: Construyendo Puentes entre la Reflexion y la Evaluación en la Universidad, Desarrollo profesoral-Universidad del Rosario
  • 2022, Taller: Emocionate y Comunica Desde la Inteligencia 1_Fecha 3, Desarrollo profesoral-Universidad del Rosario
  • 2023, Writing For Research Públication Purposes, Desarrollo profesoral-Universidad del Rosario
  • 2024, Cátedra de Integridad Científica, Desarrollo profesoral-Universidad del Rosario
  • 2025, Herramientas de Ia para la Investigación: Aplicaciones Prácticas Fecha 2, Desarrollo profesoral-Universidad del Rosario

    • Publicaciones

    Publicaciones

  • artículos académico
    • Wild-type MIC distributions and epidemiological cut-off values for ibrexafungerp, manogepix, and rezafungin against WHO fungal priority pathogens
      2026-9-1
    • Wild-type MIC distributions and Epidemiological Cut-off Values for Ibrexafungerp, Manogepix, and Rezafungin against WHO Fungal Priority Pathogens
      2026-6-1
    • Novel cyp51A mutation profile in Aspergillus fumigatus from a patient with systemic lupus erythematosus and limited systemic sclerosis: first clinical case of acquired azole-resistance in Colombia
      2026-3-2
    • Phage Display-Derived Peptides Have Neutralizing Activities Against Biofilm Formation by Candida albicans, Candidozyma auris and Candida parapsilosis
      2026-2-1
    • The Antimicrobial Peptide C14R Is Active Against All Pathogenic Species of the ESKAPE Group
      2026-2-1
    • Novel cyp51A mutation profile in Aspergillus fumigatus from a patient with systemic lupus erythematosus and limited systemic sclerosis: first clinical case of acquired azole-resistance in Colombia
      2026-12-1
    • Emerging fluconazole-resistant Candida parapsilosis in Australia: a case cluster and insights into the genetic diversity of this species
      2026-1-1
    • Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity
      2025-7-1
    • Broad Antifungal Spectrum of the Pore-Forming Peptide C14R Against Cryptococcus and Candida Species from the WHO Fungal Priority Pathogens List
      2025-6-1
    • Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
      2025-4-1
    • Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma auris
      2025-3-1
    • Amyloid fibrils of the Als5p-derived peptide NH 2 -SNGIVIVATTRTV-COOH influence the biofilm formation of Candida albicans by shape-edging microcolony morphology
      2025-12-10
    • Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans
      2025-12-1
    • Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans
      2024-7-1
    • Fatal co-infection by multiple pathogens in an indigenous woman with autoimmune hemolytic anemia and tuberculosis: a case report
      2024-6-24
    • Candida Non-albicans and Non-auris Causing Invasive Candidiasis in a Fourth-Level Hospital in Colombia: Epidemiology, Antifungal Susceptibility, and Genetic Diversity
      2024-5-1
    • Candida Non-albicans and Non-auris Causing Invasive Candidiasis in a Fourth-Level Hospital in Colombia: Epidemiology, Antifungal Susceptibility, and Genetic Diversity
      2024-4-30
    • Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
      2024-3-27
    • Occurrence of pathogenic yeast  species in artisanal cheeses from Boyacá, Colombia, including fluconazole resistant isolates
      2024-1-1
    • Antifungal resistance: a growing concern
      2023-9-5
    • In Vitro Antifungal Activity of Three Synthetic Peptides against Candida auris and Other Candida Species of Medical Importance
      2023-8-1
    • Rare Yeasts in Latin America: Uncommon Yet Meaningful
      2023-7-14
    • Cm-p5 Peptide Dimers Inhibit Biofilms of Candida albicans Clinical Isolates, C. parapsilosis and Fluconazole-Resistant Mutants of C. auris
      2023-6-6
    • Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase
      2023-6-21
    • Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important Candida Species
      2023-2-27
    • Multi-locus sequence typing and phylogenetics of Cryptococcus neoformans AD hybrids
      2023-12-19
    • Therapeutic Use of the Antimicrobial Peptide PNR20 to Resolve Disseminated Candidiasis in a Murine Model
      2023-11-28
    • Genotypic diversity and antifungal susceptibility of clinical isolates of Cryptococcus gattii species complex from Argentina
      2023-1-7
    • Cryptococcus neoformans- and Cryptococcus gattii-specific IgG, IgA and IgM differ among children and adults with and without cryptococcosis from Colombia
      2022-9-6
    • Molecular type distribution and fluconazole susceptibility of clinical Cryptococcus gattii isolates from South African laboratory-based surveillance, 2005–2013
      2022-6-29
    • Cryptococcus neoformans causing meningoencephalitis in adults and a child from Lima, Peru: genotypic diversity and antifungal susceptibility
      2022-12-16
    • Identification of disease-associated cryptococcal proteins reactive with serum IgG from cryptococcal meningitis patients
      2021-7-23
    • Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types
      2021-7-15
    • Genotype, antifungal susceptibility, and virulence of clinical South African Cryptococcus neoformans strains from National Surveillance, 2005-2009
      2021-5-1
    • Cryptococcus neoformans and Cryptococcus gattii species complexes in Latin America: a map of molecular types, genotypic diversity, and antifungal susceptibility as reported by the Latin American Cryptococcal Study Group
      2021-4-9
    • Multilocus Sequence Typing Reveals Extensive Genetic Diversity of the Emerging Fungal Pathogen Scedosporium aurantiacum
      2021-12-27
    • Clinical and epidemiological profile of patients with invasive aspergillosis from a fourth level hospital in Bogota, Colombia: a retrospective study
      2021-12-18
    • Cryptococcosis in hematopoietic stem cell transplant recipients: A rare presentation warranting recognition
      2020-8-19
    • Molecular epidemiology reveals low genetic diversity among Cryptococcus neoformans isolates from people living with HIV in Lima, Peru, during the pre-HAART
      2020-8-18
    • Rearing and maintenance of Galleria mellonella and its application to study fungal virulence
      2020-7-1
    • Indoor dust as a source of virulent strains of the agents of cryptococcosis in the Rio Negro Micro-Region of the Brazilian Amazon
      2020-5-7
    • Invasive fungal disease in humans: Are we aware of the real impact?
      2020-10-9
    • Fatal fungaemia due to Cryptococcus albidus in an elderly diabetic woman presenting with pleural effusion
      2020-1-1
    • Clonal Dispersal of Cryptococcus gattii VGII in an Endemic Region of Cryptococcosis in Colombia
      2019-6-1
    • The status of cryptococcosis in latin America
      2018-7-1
    • Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection
      2018-12-1
    • MLST and Whole-Genome-Based Population Analysis of Cryptococcus gattii VGIII Links Clinical, Veterinary and Environmental Strains, and Reveals Divergent Serotype Specific Sub-populations and Distant Ancestors
      2016-8-5
    • Fatal case of polymicrobial meningitis caused by Cryptococcus liquefaciens and Mycobacterium tuberculosis complex in a human immunodeficiency virus-infected patient
      2015-8-1
    • Pathogenic diversity amongst serotype C VGIII and VGIV Cryptococcus gattii isolates
      2015-7-8
    • Galleria mellonella model identifies highly virulent strains among all major molecular types of Cryptococcus gattii
      2014-8-18
    • MALDI-TOF MS for the identification of veterinary non-C. neoformans-C. gattii Cryptococcus spp. isolates from Italy
      2014-8-1
    • Cryptococcus gattii in North American Pacific Northwest: Whole-population genome analysis provides insights into species evolution and dispersal
      2014-7-15
    • Phenotypic differences of cryptococcus molecular types and their implications for virulence in a drosophila model of infection
      2014-7-1
    • Antifungal drug susceptibility and phylogenetic diversity among Cryptococcus isolates from dogs and cats in North America
      2014-6-1
    • Identification of the major molecular types of cryptococcus neoformans and C. gattii by hyperbranched rolling circle amplification
      2014-4-15
    • Hospital-acquired Pneumocystis pneumonia: a renewed concern?
      2014-1-1
    • Multilocus sequence typing (MLST) and M13 PCR fingerprinting revealed heterogeneity amongst Cryptococcus species obtained from Italian veterinary isolates
      2014-1-1
    • Retrospective study of the epidemiology and clinical manifestations of Cryptococcus gattii infections in Colombia from 1997-2011
      2014-1-1
    • Molecular Epidemiology Reveals Genetic Diversity amongst Isolates of the Cryptococcus neoformans/C. gattii Species Complex in Thailand
      2013-7-1
    • MALDI-TOF MS enables the rapid identification of the major molecular types within the cryptococcus neoformans/C. gattii species complex
      2012-5-29
    • Nosocomial Pneumocystis jirovecii pneumonia: Lessons from a cluster in kidney transplant recipients
      2011-12-27
    • Fatal disseminated cryptococcus gattii infection in New Mexico
      2011-12-14
    • First environmental isolation of Cryptococcus gattii serotype B, from Cúcuta, Colombia
      2011-1-1
    • Isolation of Cryptococcus gattii molecular type VGIII, from Corymbia ficifolia detritus in Colombia
      2010-1-1
    • Circulation of Streptococcus pneumoniae clone Colombia5 ST289 in nine Latin American countries
      2009-4-1
    • Informe anual de la vigilancia fenotípica y molecular de Salmonella sp. en Colombia, 2007
      2008-1-1
    • Caracterización molecular de aislamientos invasores colombianos de Streptococcus pneumoniae serotipo 5 recuperados entre 1994 y 2004.
      2006-6-1

  • capítulos
    • Enfermedades infecciosas
      2022-3-10
    • Criptococosis
      2018-11-16
    • Técnicas moleculares utilizadas en el diagnóstico y la identificación de hongos
      2018-11-15

  • contribuciones en conferencias
    • Candida no albicans y no auris causantes de candidiasis invasiva en el Hospital Universitario Mayor Méderi: epidemiología, susceptibilidad antifúngica y diversidad genética.
      2024-4-12
    • Invasive candidiasis by Candida non-albicans and non-auris in a fourth level hospital in Colombia: epidemiology, antifungal susceptibility and genetic diversity
      2024-11-1
    • Actividad antifúngica del péptido PNR20 contra Candida spp.
      2023-11-17
    • Infecciones invasivas por Candida no-albicans en un hospital de cuarto nivel en Bogotá: un acercamiento a su epidemiología y susceptibilidad antifúngica
      2023-11-17
    • Actividad antifúngica de péptidos antimicrobianos frente a aislamientos clínicos colombianos de Candida albicans y Candida auris
      2023-10-26
    • Infecciones invasivas por Candida no albicans en un hospital de cuarto nivel en Bogotá
      2023-10-26
    • Invasive infections by non-albicans Candida in a fourth level hospital in Colombia: an approach to their epidemiology and antifungal susceptibility
      2023-10-23
    • Epidemiología de la aspergilosis invasiva en un hospital de cuarto nivel en Bogotá, Colombia
      2021-11-25
    • Retrospective study of the clinical and epidemiological profile of patients with invasive aspergillosis in a fourth level hospital in Bogota, Colombia
      2021-11-18
    • Epidemiología de la aspergilosis invasiva en la Fundación Cardioinfantil: un estudio retrospectivo
      2021-11-12
    • Antifungal susceptibility of clinical Cryptococcus gattii isolates from Colombia varies among molecular types
      2021-10-10
    • Development and evaluation of antimicrobial peptides from the Scarabaeidae coleopteran family against pathogenic yeasts with public health impact.
      2021-10-10
    • Immunoglobulin subclass levels in cryptococcosis patients from Colombia
      2021-10-10
    • Investigating the humoral immune response against Cryptococcus neoformans in patients with cryptococcal meningitis and in healthy persons with presumed environmental exposure
      2020-9-15
    • Fatal case of Cryptococcus albidus fungaemia in an elderly immunocompromised woman presented with pleural effusion (Francia)
      2019-10-1
    • Meta-analysis of published molecular epidemiology data of the Cryptococcus neoformans and C. gattii species complexes using the ISHAM MLST consensus
      2018-7-1
    • Multilocus sequence typing of the agents of cryptococcosis in the Rio Negro river basin, Brazilian Amazon region
      2018-6-6
    • Immunoproteomic analysis of Cryptococcus neoformans antigens reactive with sera from patients with cryptococcosis in Colombia
      2018-11-17

  • artículos editorial
    • Recent advances in Cryptococcus and cryptococcosis
      2021-12-23

  • cartas
    • In vitro evaluation of Ibrexafungerp against clinical and environmental isolates of Cryptococcus neoformans and Cryptococcus gattii
      2025-12-1
    • Molecular epidemiology linking multihospital clusters of opportunistic Pneumocystis jirovecii pneumonia
      2013-10-1

  • resumen
    • Caso fatal de meningitis por Cryptococcus neoformans en una paciente mayor con cirrosis y diabetes mellitus
      2024-11-14
    • Aislamientos clínicos colombianos de Cryptococcus neoformans y Cryptococcus gattii desarrollan heterorresistencia a fluconazol en altas concentraciones de este triazol
      2021-11-25
    • Genotypic diversity of clinical isolates of Cryptococcus gattii species complex from Argentina
      2021-11-19
    • Molecular epidemiology of Cryptococcus neoformans and Cryptococcus gattii in Latin America
      2018-7-1

    • Proyectos

    Investigador Principal

  • Caracterización genómica y de susceptibilidad a los antibióticos de aislamientos colombianos de Campylobacter jejuni causantes de enfermedad diarreica aguda y los asociados con el síndrome de Guillain-Barré captados por la vigilancia nacional 2023-08-08 - 2027-07-31
  • Epidemiología de la criptococosis en un hospital de cuarto nivel en Bogotá, Colombia: un estudio retrospectivo 2025-09-22 - 2027-03-22
  • Evaluar el efecto antifúngico del péptido derivado de moluscos Cm-p5 y sus derivados contra la levadura oportunista prevalente Cándida albicans y la levadura emergente multirresistente Candida auris. 2022-02-10 - 2024-12-31
  • Caracterización de levaduras atípicas en el Hospital Universitario Mayor Méderi: identificación molecular, susceptibilidad anti fúngica y características epidemiológicas de pacientes infectados. 2021-12-17 - 2023-12-16
  • Determinación de los principales mecanismos asociados con resistencia al fluconazol en aislamientos colombianos clínicos y ambientales de Cryptococcus neoformans y Cryptococcus gattii 2020-03-13 - 2022-12-02
  • Determination of antibodies against Cryptococcus neoformans and C. gattii proteins in sera of healthy and cryptococcosis Colombian children and adults. 2018-03-01 - 2021-06-30

    • Coinvestigador

  • Molecular epidemiology, genomics, population genetics analysis and pathogenesis of the members of the Cryptococcus neoformans and C. gattii species complexes and other fungal species of clinical importance 2018-06-01 - 2026-12-31
  • Evaluación de la capacidad anti fúngica de péptidos sintéticos antibacterianos contra aislamientos clínicos de la levadura emergente, multirresistente Candida auris recuperados en Colombia y otras especies de Cándida de importancia en salud pública. 2020-11-06 - 2023-11-06
  • Encuesta latinoamericana sobre la resistencia de Aspergillus fumigatus a los asoles en 12 países, 20 laboratorios. 2021-09-01 - 2023-08-31
  • Desarrollo de péptidos antimicrobianos a partir de péptidos de defensa del hospedero (HDPs) de coleópteros de la familia Scarabaeidae y su evaluación frente a microorganismos causantes de infecciones asociadas a la atención en salud. 2020-01-30 - 2023-01-30
  • Epidemiología de la aspergilosis invasiva en un hospital de cuarto nivel en Bogotá, Colombia: un estudio retrospectivo 2020-01-10 - 2021-07-31
  • Immunoproteomic analysis of antigens recognized by human patients with cryptococcosis 2018-05-01 - 2019-12-31

    • Tutorías

    Tutorías

  • Niveles de anticuerpos totales y específicos contra proteínas de Cryptococcus neoformans y Cryptococcus gattii en sueros de adultos y niños colombianos con y sin diagnóstico de criptococosis Tesis
  • Niveles de anticuerpos totales y específicos contra proteínas de Cryptococcus neoformans y Cryptococcus gattii en sueros de adultos y niños colombianos con y sin diagnóstico de Criptococosis Tesis

    • Reconocimientos

    Premios Y Honores

  • Tercer lugar en el concurso de trabajos de investigación en modalidad de 'Protocolo con resultados completos”, 2024
  • Tercer puesto en el concurso de póster de investigación de Méderi, 2019

    • Identidad

    Nombre De Autor

  • Sandra Carolina Firacative Ropero

    • Mejore su perfil